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Improved long-term expression from helper virus-free HSV-1 vectors packaged using combinations of mutated HSV-1 proteins that include the U(L)13 protein kinase and specific components of the VP16 transcriptional complex

BACKGROUND: Herpes Simplex Virus (HSV-1) gene expression is thought to shut off recombinant gene expression from HSV-1 vectors; however, in a helper virus-free HSV-1 vector system, a number of promoters support only short-term expression. These results raise the paradox that recombinant gene express...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Liu, Meng, Wang, Xiaodan, Geller, Alfred I
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709626/
https://ncbi.nlm.nih.gov/pubmed/19531264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-10-58
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