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Inhibition of Lipid A Biosynthesis as the Primary Mechanism of CHIR-090 Antibiotic Activity in Escherichia coli

The deacetylation of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine (UDP-3-O-acyl-GlcNAc) by LpxC is the committed reaction of lipid A biosynthesis. CHIR-090, a novel N-aroyl-l-threonine hydroxamic acid, is a potent, slow, tight-binding inhibitor of the LpxC deacetylase from the hyperthermophile...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Barb, Adam W., McClerren, Amanda L., Snehelatha, Karnem, Reynolds, C. Michael, Zhou, Pei, Raetz, Christian R.H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2007
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709454/
https://ncbi.nlm.nih.gov/pubmed/17335290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi6025165
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