Lack of CFTR in Skeletal Muscle Predisposes to Muscle Wasting and Diaphragm Muscle Pump Failure in Cystic Fibrosis Mice

Cystic fibrosis (CF) patients often have reduced mass and strength of skeletal muscles, including the diaphragm, the primary muscle of respiration. Here we show that lack of the CF transmembrane conductance regulator (CFTR) plays an intrinsic role in skeletal muscle atrophy and dysfunction. In norma...

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Detalhes bibliográficos
Main Authors: Divangahi, Maziar, Balghi, Haouaria, Danialou, Gawiyou, Comtois, Alain S., Demoule, Alexandre, Ernest, Sheila, Haston, Christina, Robert, Renaud, Hanrahan, John W., Radzioch, Danuta, Petrof, Basil J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709446/
https://ncbi.nlm.nih.gov/pubmed/19649303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000586
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