FANCJ Helicase Uniquely Senses Oxidative Base Damage in Either Strand of Duplex DNA and Is Stimulated by Replication Protein A to Unwind the Damaged DNA Substrate in a Strand-specific Manner

FANCJ mutations are genetically linked to the Fanconi anemia complementation group J and predispose individuals to breast cancer. Understanding the role of FANCJ in DNA metabolism and how FANCJ dysfunction leads to tumorigenesis requires mechanistic studies of FANCJ helicase and its protein partners...

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Detalhes bibliográficos
Main Authors: Suhasini, Avvaru N., Sommers, Joshua A., Mason, Aaron C., Voloshin, Oleg N., Camerini-Otero, R. Daniel, Wold, Marc S., Brosh, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709400/
https://ncbi.nlm.nih.gov/pubmed/19419957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.012229
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