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Substrate Recognition of Anthrax Lethal Factor Examined by Combinatorial and Pre-steady-state Kinetic Approaches

Lethal factor (LF), a zinc-dependent protease of high specificity produced by Bacillus anthracis, is the effector component of the binary toxin that causes death in anthrax. New therapeutics targeting the toxin are required to reduce systemic anthrax-related fatalities. In particular, new insights i...

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Bibliografski detalji
Glavni autori: Zakharova, Maria Yu., Kuznetsov, Nikita A., Dubiley, Svetlana A., Kozyr, Arina V., Fedorova, Olga S., Chudakov, Dmitry M., Knorre, Dmitry G., Shemyakin, Igor G., Gabibov, Alexander G., Kolesnikov, Alexander V.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709388/
https://ncbi.nlm.nih.gov/pubmed/19359249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807510200
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