Substrate Recognition of Anthrax Lethal Factor Examined by Combinatorial and Pre-steady-state Kinetic Approaches

Lethal factor (LF), a zinc-dependent protease of high specificity produced by Bacillus anthracis, is the effector component of the binary toxin that causes death in anthrax. New therapeutics targeting the toxin are required to reduce systemic anthrax-related fatalities. In particular, new insights i...

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Autors principals: Zakharova, Maria Yu., Kuznetsov, Nikita A., Dubiley, Svetlana A., Kozyr, Arina V., Fedorova, Olga S., Chudakov, Dmitry M., Knorre, Dmitry G., Shemyakin, Igor G., Gabibov, Alexander G., Kolesnikov, Alexander V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Enzyme Catalysis and Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709388/
https://ncbi.nlm.nih.gov/pubmed/19359249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807510200
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