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Energy profile and secondary structure impact shRNA efficacy

BACKGROUND: RNA interference (RNAi) is a cellular mechanism in which a short/small double stranded RNA induces the degradation of its sequence specific target mRNA, leading to specific gene silencing. Since its discovery, RNAi has become a powerful biological technique for gene function studies and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Hong, Zeng, Xiao
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709270/
https://ncbi.nlm.nih.gov/pubmed/19594886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-10-S1-S9
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