Antigen Specificity of Clonally Expanded and Receptor Edited Cerebrospinal Fluid B cells from Patients with Relapsing Remitting MS

We re-engineered the immunoglobulin rearrangements from clonally expanded CSF B cells of three Multiple Sclerosis patients as Fab fragments, and used three methods to test for their Ag-specificity. Nine out of ten Fab fragments were reactive to Myelin Basic Protein (MBP). The one Fab that did not re...

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Bibliographic Details
Main Authors: Lambracht-Washington, Doris, O’Connor, Kevin C., Cameron, Elizabeth, Jowdry, Andrea, Ward, E. Sally, Frohman, Elliot, Racke, Michael K., Monson, Nancy L.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709235/
https://ncbi.nlm.nih.gov/pubmed/17451814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2007.03.002
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