A Label-free Quantitative Proteomics Strategy to Identify E3 Ubiquitin Ligase Substrates Targeted to Proteasome Degradation

The ubiquitin-proteasome system is a central mechanism for controlled proteolysis that regulates numerous cellular processes in eukaryotes. As such, defects in this system can contribute to disease pathogenesis. In this pathway, E3 ubiquitin ligases provide platforms for binding specific substrates,...

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Detalhes bibliográficos
Main Authors: Burande, Clara F., Heuzé, Mélina L., Lamsoul, Isabelle, Monsarrat, Bernard, Uttenweiler-Joseph, Sandrine, Lutz, Pierre G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709196/
https://ncbi.nlm.nih.gov/pubmed/19376791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M800410-MCP200
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