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Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

Extensive genetic, biochemical, and histological evidence has implicated the amyloid-β peptide (Aβ) in Alzheimer's disease pathogenesis, and several mechanisms have been suggested, such as metal binding, reactive oxygen species production, and membrane pore formation. However, recent evidence a...

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Detalhes bibliográficos
Autor principal: Bredesen, Dale E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709109/
https://ncbi.nlm.nih.gov/pubmed/19558683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-27
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