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Structural and functional implications of p53 missense cancer mutations

Most human cancers contain mutations in the transcription factor p53 and majority of these are missense and located in the DNA binding core domain. In this study, the stabilities of all core domain missense mutations are predicted and are used to infer their likely inactivation mechanisms. Overall,...

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Bibliografiske detaljer
Main Authors: Tan, Yuhong, Luo, Ray
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709103/
https://ncbi.nlm.nih.gov/pubmed/19558684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1757-5036-2-5
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