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Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation
Mutations of the sequence-specific master regulator p53 that alter transactivation function from promoter response elements (REs) could result in changes in the strength of gene activation or spectra of genes regulated. Such mutations in this tumor suppressor might lead to dramatic phenotypic change...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2873663/ https://ncbi.nlm.nih.gov/pubmed/20407015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0442 |
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