Chimeric transcript discovery by paired-end transcriptome sequencing

Recurrent gene fusions are a prevalent class of mutations arising from the juxtaposition of 2 distinct regions, which can generate novel functional transcripts that could serve as valuable therapeutic targets in cancer. Therefore, we aim to establish a sensitive, high-throughput methodology to compr...

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Main Authors: Maher, Christopher A., Palanisamy, Nallasivam, Brenner, John C., Cao, Xuhong, Kalyana-Sundaram, Shanker, Luo, Shujun, Khrebtukova, Irina, Barrette, Terrence R., Grasso, Catherine, Yu, Jindan, Lonigro, Robert J., Schroth, Gary, Kumar-Sinha, Chandan, Chinnaiyan, Arul M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708976/
https://ncbi.nlm.nih.gov/pubmed/19592507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904720106
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