Modulation of Gonadotropin-Releasing Hormone Pulse Generator Sensitivity to Progesterone Inhibition in Hyperandrogenic Adolescent Girls—Implications for Regulation of Pubertal Maturation

Context: Adult women with polycystic ovary syndrome (PCOS) have decreased GnRH pulse generator sensitivity to progesterone (P)-mediated slowing. This defect is androgen mediated because it is reversed with androgen receptor blockade. Adolescent hyperandrogenism often precedes PCOS. Objective: The ai...

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Detalhes bibliográficos
Main Authors: Blank, Susan K., McCartney, Christopher R., Chhabra, Sandhya, Helm, Kristin D., Eagleson, Christine A., Chang, R. Jeffrey, Marshall, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708962/
https://ncbi.nlm.nih.gov/pubmed/19351732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2008-2606
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