Discovery and Exploitation of Inhibitor-resistant Aurora and Polo Kinase Mutants for the Analysis of Mitotic Networks

The Aurora and Polo-like kinases are central components of mitotic signaling pathways, and recent evidence suggests that substantial cross-talk exists between Aurora A and Plk1. In addition to their validation as novel anticancer agents, small molecule kinase inhibitors are increasingly important to...

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Bibliographic Details
Main Authors: Scutt, Paul J., Chu, Matthew L. H., Sloane, Dominic A., Cherry, Mike, Bignell, Colin R., Williams, David H., Eyers, Patrick A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708884/
https://ncbi.nlm.nih.gov/pubmed/19359241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005694
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