Inhibition of Furin/Proprotein Convertase-catalyzed Surface and Intracellular Processing by Small Molecules

Furin is a ubiquitously expressed proprotein convertase (PC) that plays a vital role in numerous disease processes including cancer metastasis, bacterial toxin activation (e.g. anthrax and Pseudomonas), and viral propagation (e.g. avian influenza and human immunodeficiency virus). To identify small...

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Main Authors: Komiyama, Tomoko, Coppola, Julia M., Larsen, Martha J., van Dort, Marcian E., Ross, Brian D., Day, Robert, Rehemtulla, Alnawaz, Fuller, Robert S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Protein Synthesis, Post-Translational Modification, and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708870/
https://ncbi.nlm.nih.gov/pubmed/19332539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901540200
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