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Alanine Scanning of the S6 Segment Reveals a Unique and cAMP-sensitive Association between the Pore and Voltage-dependent Opening in HCN Channels
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels resemble Shaker K(+) channels in structure and function. In both, changes in membrane voltage produce directionally similar movement of positively charged residues in the voltage sensor to alter the pore structure at the intracel...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708862/ https://ncbi.nlm.nih.gov/pubmed/19269964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809164200 |
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