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Regulation of Microtubule Dynamic Instability in Vitro by Differentially Phosphorylated Stathmin

Stathmin is an important regulator of microtubule polymerization and dynamics. When unphosphorylated it destabilizes microtubules in two ways, by reducing the microtubule polymer mass through sequestration of soluble tubulin into an assembly-incompetent T2S complex (two α:β tubulin dimers per molecu...

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Main Authors: Manna, Tapas, Thrower, Douglas A., Honnappa, Srinivas, Steinmetz, Michel O., Wilson, Leslie
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708860/
https://ncbi.nlm.nih.gov/pubmed/19359244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M900343200
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