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Phosphorylation disrupts the central helix in Op18/stathmin and suppresses binding to tubulin

Protein phosphorylation represents a ubiquitous control mechanism in living cells. The structural prerequisites and consequences of this important post-translational modification, however, are poorly understood. Oncoprotein 18/stathmin (Op18) is a globally disordered phosphoprotein that is involved...

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Detalhes bibliográficos
Main Authors: Steinmetz, Michel O., Jahnke, Wolfgang, Towbin, Harry, García-Echeverría, Carlos, Voshol, Hans, Müller, Dieter, van Oostrum, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083899/
https://ncbi.nlm.nih.gov/pubmed/11415983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve105
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