Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase

Microglial-related factors have been implicated in the signaling cascades that contribute to neuronal cell death in various neurodegenerative disorders. Thus, strategies that reduce microglial activation and associated neurotoxicity may have therapeutic benefit. Group II and III metabotropic glutama...

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Bibliografske podrobnosti
Main Authors: Loane, David J., Stoica, Bogdan A., Pajoohesh-Ganji, Ahdeah, Byrnes, Kimberly R., Faden, Alan I.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Mechanisms of Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708859/
https://ncbi.nlm.nih.gov/pubmed/19364772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806139200
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