Endothelin-Converting Enzyme-2 Is Increased in Alzheimer’s Disease and Up-Regulated by Aβ

Alzheimer’s disease (AD) is thought to be caused by the accumulation of amyloid beta (Aβ) peptide within the brain. Endothelin-converting enzyme-2 (ECE-2), which is expressed in neural tissues, cleaves ‘big endothelin’ to produce the vasoconstrictor endothelin-1. ECE-2 also degrades Aβ. We have exam...

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Bibliografiske detaljer
Main Authors: Palmer, Jennifer C., Baig, Shabnam, Kehoe, Patrick G., Love, Seth
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2009
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708812/
https://ncbi.nlm.nih.gov/pubmed/19541930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.081054
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