Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity
Single-chain antibody mutants have been evolved in vitro with antigen-binding equilibrium dissociation constant K(d) = 48 fM and slower dissociation kinetics (half-time > 5 days) than those for the streptavidin–biotin complex. These mutants possess the highest monovalent ligand-binding affinity yet...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27086/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10984501/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.170297297 |
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