Bivalent Recombinant Vaccine for Botulinum Neurotoxin Types A and B Based on a Polypeptide Comprising Their Effector and Translocation Domains That Is Protective against the Predominant A and B Subtypes

The botulinum neurotoxins (BoNTs) are a large family of extremely potent, neuroparalytic, dichain proteins which act at the peripheral nervous system. The wide genetic diversity observed with this neurotoxin family poses a significant challenge for the development of an effective botulinum vaccine....

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Bibliographische Detailangaben
Hauptverfasser: Shone, Clifford, Agostini, Heidi, Clancy, Joanna, Gu, Mili, Yang, Huei-Hsiung, Chu, Yanfang, Johnson, Virginia, Taal, Makie, McGlashan, Joanna, Brehm, John, Tong, Xiaomi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708551/
https://ncbi.nlm.nih.gov/pubmed/19398544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01252-08
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