Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells

The lipid mediator sphingosine-1-phosphate (S1P), the product of sphingosine kinase (SPHK)-induced phosphorylation of sphingosine, is known to stabilize interendothelial junctions and prevent microvessel leakiness. Here, we investigated the role of SPHK1 activation in regulating the increase in pulm...

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Detalhes bibliográficos
Main Authors: Tauseef, Mohammad, Kini, Vidisha, Knezevic, Nebojsa, Brannan, Melissa, Ramchandaran, Ram, Fyrst, Henrik, Saba, Julie, Vogel, Stephen M., Malik, Asrar B., Mehta, Dolly
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708004/
https://ncbi.nlm.nih.gov/pubmed/18849324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.RES.0000338501.84810.51
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