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The Cataract-associated R14C Mutant of Human γD-Crystallin Shows a Variety of Intermolecular Disulfide Crosslinks: A Raman Spectroscopic Study
The Arg14 to Cys (R14C) mutation in the human γD-crystallin (HGD) gene has been associated with a juvenile-onset hereditary cataract. We showed earlier (1) that rapid oxidation of Cys14 in the mutant leads to the formation of intermolecular, disulfide-crosslinked aggregates at physiological pH. Here...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2707855/ https://ncbi.nlm.nih.gov/pubmed/19382745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9004182 |
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