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Heterozygosity for Hypoxia Inducible Factor 1α decreases the incidence of thymic lymphomas in a p53 mutant mouse model
Hypoxia Inducible Factors (HIFs) are critical mediators of the cellular response to decreased oxygen tension and are overexpressed in a number of tumors. While HIF1α and HIF2α share a high degree of sequence homology, recent work has shown that the two α subunits can have contrasting and tissue-spec...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2707815/ https://ncbi.nlm.nih.gov/pubmed/19293180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4223 |
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