Shikonin Exerts Antitumor Activity via Proteasome Inhibition and Cell Death Induction in vitro and in vivo

Dysregulation of the ubiquitin-proteasome pathway plays an essential role in tumor growth and development. Shikonin, a natural naphthoquinone isolated from the traditional Chinese medicine Zi Cao (gromwell), has been reported to possess tumor cell-killing activity, and results from a clinical study...

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Autors principals: Yang, Huanjie, Zhou, Ping, Huang, Hongbiao, Chen, Di, Ma, Ningfang, Cui, Cindy Qiuzhi, Shen, Shouxing, Dong, Weihua, Zhang, Xiaoyan, Lian, Wen, Wang, Xuejun, Dou, Q. Ping, Liu, Jinbao
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707765/
https://ncbi.nlm.nih.gov/pubmed/19165859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24195
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