Physiological levels of ATP Negatively Regulate Proteasome Function

Intracellular protein degradation by the ubiquitin-proteasome system is ATP-dependent and the optimal ATP concentration to activate proteasome function in vitro is ~100 μM. Intracellular ATP levels are generally in the low millimolar range but ATP at a level within this range was shown to inhibit pr...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Huang, Hongbiao, Zhang, Xiaoyan, Li, Shujue, Liu, Ningning, Lian, Wen, McDowell, Emily, Zhou, Ping, Zhao, Canguo, Guo, Haiping, Zhang, Change, Yang, Changshan, Wen, Guangmei, Dong, Xiaoxian, Lu, Li, Ma, Ningfang, Dong, Weihua, Dou, Q. Ping, Wang, Xuejun, Liu, Jinbao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996470/
https://ncbi.nlm.nih.gov/pubmed/20805844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2010.123
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky