Physiological levels of ATP Negatively Regulate Proteasome Function

Intracellular protein degradation by the ubiquitin-proteasome system is ATP-dependent and the optimal ATP concentration to activate proteasome function in vitro is ~100 μM. Intracellular ATP levels are generally in the low millimolar range but ATP at a level within this range was shown to inhibit pr...

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Autori principali: Huang, Hongbiao, Zhang, Xiaoyan, Li, Shujue, Liu, Ningning, Lian, Wen, McDowell, Emily, Zhou, Ping, Zhao, Canguo, Guo, Haiping, Zhang, Change, Yang, Changshan, Wen, Guangmei, Dong, Xiaoxian, Lu, Li, Ma, Ningfang, Dong, Weihua, Dou, Q. Ping, Wang, Xuejun, Liu, Jinbao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996470/
https://ncbi.nlm.nih.gov/pubmed/20805844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2010.123
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