Syk Tyrosine 317 Negatively Regulates Osteoclast Function via the Ubiquitin-Protein Isopeptide Ligase Activity of Cbl

Cytoskeletal organization of the osteoclast (OC), which is central to the capacity of the cell to resorb bone, is induced by occupancy of the αvβ3 integrin or the macrophage colony-stimulating factor (M-CSF) receptor c-Fms. In both circumstances, the tyrosine kinase Syk is an essential signaling int...

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Bibliographic Details
Main Authors: Zou, Wei, Reeve, Jennifer L., Zhao, Haibo, Ross, F. Patrick, Teitelbaum, Steven L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707246/
https://ncbi.nlm.nih.gov/pubmed/19419964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.012385
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