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Phosphorylation of p27(Kip1) by Epstein-Barr Virus Protein Kinase Induces Its Degradation through SCF(Skp2) Ubiquitin Ligase Actions during Viral Lytic Replication
Epstein-Barr virus (EBV) productive replication occurs in an S-phase-like cellular environment with high cyclin-dependent kinase (CDK) activity. The EBV protein kinase (PK), encoded by the viral BGLF4 gene, is a Ser/Thr protein kinase, which phosphorylates both viral and cellular proteins, modifying...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2707218/ https://ncbi.nlm.nih.gov/pubmed/19451650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.015123 |
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