Degradation of Phosphorylated p53 by Viral Protein-ECS E3 Ligase Complex

p53-signaling is modulated by viruses to establish a host cellular environment advantageous for their propagation. The Epstein-Barr virus (EBV) lytic program induces phosphorylation of p53, which prevents interaction with MDM2. Here, we show that induction of EBV lytic program leads to degradation o...

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Autori principali: Sato, Yoshitaka, Kamura, Takumi, Shirata, Noriko, Murata, Takayuki, Kudoh, Ayumi, Iwahori, Satoko, Nakayama, Sanae, Isomura, Hiroki, Nishiyama, Yukihiro, Tsurumi, Tatsuya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712087/
https://ncbi.nlm.nih.gov/pubmed/19649319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000530
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