Phosphorylation of p27(Kip1) by Epstein-Barr Virus Protein Kinase Induces Its Degradation through SCF(Skp2) Ubiquitin Ligase Actions during Viral Lytic Replication

Epstein-Barr virus (EBV) productive replication occurs in an S-phase-like cellular environment with high cyclin-dependent kinase (CDK) activity. The EBV protein kinase (PK), encoded by the viral BGLF4 gene, is a Ser/Thr protein kinase, which phosphorylates both viral and cellular proteins, modifying...

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Detalhes bibliográficos
Main Authors: Iwahori, Satoko, Murata, Takayuki, Kudoh, Ayumi, Sato, Yoshitaka, Nakayama, Sanae, Isomura, Hiroki, Kanda, Teru, Tsurumi, Tatsuya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707218/
https://ncbi.nlm.nih.gov/pubmed/19451650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.015123
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