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Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase

Highly potent and selective inhibitors of neuronal nitric oxide synthase (nNOS) possessing a 2-aminopyridine group were recently designed and synthesized in our laboratory and were shown to have significant in vivo efficacy. In this work, analogs of our lead compound possessing 2- and 4-aminothiazol...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Lawton, Graham R, Ji, Haitao, Martásek, Pavel, Roman, Linda J, Silverman, Richard B
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Beilstein-Institut 2009
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707017/
https://ncbi.nlm.nih.gov/pubmed/19590740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.5.28
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