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Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function

Germline and somatic PTEN mutations are found in Cowden syndrome (CS) and multiple sporadic malignancies, respectively. PTEN function appears to be modulated by subcellular compartmentalization, and mislocalization may affect function. We have shown that cellular ATP levels affect nuclear PTEN level...

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Bibliografski detalji
Glavni autori: Lobo, Glenn P., Waite, Kristin A., Planchon, Sarah M., Romigh, Todd, Nassif, Najah T., Eng, Charis
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706686/
https://ncbi.nlm.nih.gov/pubmed/19457929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp220
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