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Genetic Background Comparison Using Distance-based Regression, with Applications in Population Stratification Evaluation and Adjustment
Population stratification (PS) can lead to an inflated rate of false positive findings in genome-wide association studies (GWAS). A commonly used approach is to adjust for a fixed number of principal components (PCs) in GWAS but this approach could have a deleterious impact on power when the cases a...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2706300/ https://ncbi.nlm.nih.gov/pubmed/19140130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20396 |
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