A two step model for colon adenoma initiation and progression caused by APC loss

Aberrant Wnt/β-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Using zebrafish and human cells, we show that homozygous loss of APC causes failed intestinal cell differentiation, but that this occurs in the abs...

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Detalhes bibliográficos
Main Authors: Phelps, Reid A., Chidester, Stephanie, Dehghanizadeh, Somaye, Phelps, Jason, Sandoval, Imelda T., Rai, Kunal, Broadbent, Talmage, Sarkar, Sharmistha, Burt, Randall W., Jones, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706149/
https://ncbi.nlm.nih.gov/pubmed/19450512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.02.037
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