DNA Demethylase Activity Maintains Intestinal Cells in an Undifferentiated State Following Loss of APC

Although genome-wide hypomethylation is a hallmark of many cancers, roles for active DNA demethylation during tumorigenesis are unknown. Here, loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system and the concomitant hypomethylation of key intestinal cell fating genes...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Rai, Kunal, Sarkar, Sharmistha, Broadbent, Talmage J., Voas, Matthew, Grossmann, Kenneth F., Nadauld, Lincoln D., Dehghanizadeh, Somaye, Hagos, Fanuel T., Li, Yumei, Toth, Rachel K., Chidester, Stephanie, Bahr, Timothy M., Johnson, W. Evan, Sklow, Brad, Burt, Randall, Cairns, Bradley R., Jones, David A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943938/
https://ncbi.nlm.nih.gov/pubmed/20850014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.08.030
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