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Regulation of VDR expression in Apc mutant mice, human colon cancers and adenomas

One variable that may impact the ability of vitamin D to reduce colon cancer risk is the expression of its high affinity receptor, VDR. Here we show that vitamin D does not reduce tumor formation in Apc(Δ14/+) mice and that VDR expression is lost in the majority of the colon tumor cells. The extent...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Prev Res (Phila)
Prif Awduron: Giardina, Charles, Nakanishi, Masako, Khan, Awaad, Kuratnik, Anton, Xu, Wanli, Brenner, Bruce, Rosenberg, Daniel W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417398/
https://ncbi.nlm.nih.gov/pubmed/25873367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-14-0371
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