Homology Modeling and Site-directed Mutagenesis to Identify Selective Inhibitors of Endothelin-Converting Enzyme-2

Endothelin-converting enzyme-2 (ECE-2), a member of M13 family of zinc metallopeptidases, has previously been shown to process a number of neuropeptides including those derived from prodynorphin, proenkephalin, proSAAS and amyloid precursor protein. ECE-2, unlike ECE-1, exhibits restricted neuroendo...

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Autores principales: Gagnidze, Khatuna, Sachchidanand, Rozenfeld, Raphael, Mezei, Mihaly, Zhou, Ming-Ming, Devi, Lakshmi A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706147/
https://ncbi.nlm.nih.gov/pubmed/18507370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm7015478
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