Identification of an Endothelin-converting Enzyme-2-specific Fluorigenic Substrate and Development of an in Vitro and ex Vivo Enzymatic Assay

Endothelin-converting enzyme-2 (ECE-2) is a membrane-bound zinc-dependent metalloprotease that shares a high degree of sequence homology with ECE-1, but displays an acidic pH optimum characteristic of maturing enzymes acting late in the secretory pathway. Although ECE-2, like ECE-1, can cleave the b...

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Main Authors: Ouimet, Tanja, Orng, Sou-Vinh, Poras, Hervé, Gagnidze, Khatuna, Devi, Lakshmi A., Fournié-Zaluski, Marie-Claude, Roques, Bernard P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
Ábhair:
Enzymology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966053/
https://ncbi.nlm.nih.gov/pubmed/20807771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.120576
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