Detection and Quantification of Botulinum Neurotoxin Type A by a Novel Rapid In Vitro Fluorimetric Assay

Botulinum neurotoxin type A (BoNT/A), the most poisonous substance known to humans, is a potential bioterrorism agent. The light-chain protein induces a flaccid paralysis through cleavage of the 25-kDa synaptosome-associated protein (SNAP-25), involved in acetylcholine release at the neuromuscular j...

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Main Authors: Poras, Hervé, Ouimet, Tanja, Orng, Sou-Vinh, Fournié-Zaluski, Marie-Claude, Popoff, Michel R., Roques, Bernard P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
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Methods
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704824/
https://ncbi.nlm.nih.gov/pubmed/19429547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00091-09
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