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Cooperativity Dominates the Genomic Organization of p53-Response Elements: A Mechanistic View

p53-response elements (p53-REs) are organized as two repeats of a palindromic DNA segment spaced by 0 to 20 base pairs (bp). Several experiments indicate that in the vast majority of the human p53-REs there are no spacers between the two repeats; those with spacers, particularly with sizes beyond tw...

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Autori principali: Pan, Yongping, Nussinov, Ruth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705680/
https://ncbi.nlm.nih.gov/pubmed/19629163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000448
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