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Phosphorylation within an Autoinhibitory Domain in Endothelial Nitric Oxide Synthase Reduces the Ca(2+) Concentrations Required for Calmodulin To Bind and Activate the Enzyme
We have investigated the effects of phosphorylation at Ser-617 and Ser-635 within an autoinhibitory domain (residues 595–639) in bovine endothelial nitric oxide synthase on enzyme activity and the Ca(2+) dependencies for calmodulin binding and enzyme activation. A phosphomimetic S617D substitution d...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2705658/ https://ncbi.nlm.nih.gov/pubmed/18558722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8003186 |
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