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Phosphorylation within an Autoinhibitory Domain in Endothelial Nitric Oxide Synthase Reduces the Ca(2+) Concentrations Required for Calmodulin To Bind and Activate the Enzyme

We have investigated the effects of phosphorylation at Ser-617 and Ser-635 within an autoinhibitory domain (residues 595–639) in bovine endothelial nitric oxide synthase on enzyme activity and the Ca(2+) dependencies for calmodulin binding and enzyme activation. A phosphomimetic S617D substitution d...

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Sonraí Bibleagrafaíochta
Main Authors: Tran, Quang-Kim, Leonard, Jared, Black, DJ, Persechini, Anthony
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705658/
https://ncbi.nlm.nih.gov/pubmed/18558722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8003186
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