CCR2 promotes hepatic fibrosis in mice

Chemokines and chemokine receptors contribute to the migration of hepatic stellate cells (HSCs) and Kupffer cells, two key cells during fibrogenesis. Here, we investigate the role of CCR2, the receptor for MCP-1, MCP-2 and MCP-3, in hepatic fibrosis. Hepatic CCR2, MCP-1, MCP-2 and MCP-3 mRNA express...

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Autors principals: Seki, Ekihiro, De Minicis, Samuele, Inokuchi, Sayaka, Taura, Kojiro, Miyai, Katsumi, Van Rooijen, Nico, Schwabe, Robert F., Brenner, David A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2705470/
https://ncbi.nlm.nih.gov/pubmed/19441102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22952
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