Ultrasensitive Genotypic Detection of Antiviral Resistance in Hepatitis B Virus Clinical Isolates

Amino acid substitutions that confer reduced susceptibility to antivirals arise spontaneously through error-prone viral polymerases and are selected as a result of antiviral therapy. Resistance substitutions first emerge in a fraction of the circulating virus population, below the limit of detection...

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Detalhes bibliográficos
Main Authors: Fang, Jie, Wichroski, Michael J., Levine, Steven M., Baldick, Carl J., Mazzucco, Charles E., Walsh, Ann W., Kienzle, Bernadette K., Rose, Ronald E., Pokornowski, Kevin A., Colonno, Richard J., Tenney, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704686/
https://ncbi.nlm.nih.gov/pubmed/19433559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00130-09
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