Susceptibility of Highly Pathogenic H5N1 Influenza Viruses to the Neuraminidase Inhibitor Oseltamivir Differs In Vitro and in a Mouse Model

While the neuraminidase (NA) inhibitor oseltamivir is currently our first line of defense against a pandemic threat, there is little information about whether in vitro testing can predict the in vivo effectiveness of antiviral treatment. Using a panel of five H5N1 influenza viruses (H5 clades 1 and...

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Detalhes bibliográficos
Main Authors: Govorkova, Elena A., Ilyushina, Natalia A., McClaren, Jennifer L., Naipospos, Tri S. P., Douangngeun, Bounlom, Webster, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704685/
https://ncbi.nlm.nih.gov/pubmed/19349520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01667-08
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