Maternal administration of anti-angiogenic agents, TNP-470 and Angiostatin(4.5), induces fetal microphthalmia

PURPOSE: Agents specifically targeting the vasculature as a mode of therapy are finding increasing use in the clinic, primarily in the treatment of colon cancer (Avastin™) and age-related macular degeneration (Lucentis™). We have previously shown that maternal administration of angiogenic inhibitors...

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Main Authors: Rutland, Catrin S., Jiang, Keyi, Soff, Gerald A., Mitchell, Christopher A.
Format: Artigo
Jezik:Inglês
Izdano: Molecular Vision 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704144/
https://ncbi.nlm.nih.gov/pubmed/19572040
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