Infectious tolerance via the consumption of essential amino acids and mTOR signaling

Infectious tolerance describes the process of CD4(+) regulatory T cells (Tregs) converting naïve T cells to become additional Tregs. We show that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (...

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Autori principali: Cobbold, Stephen P., Adams, Elizabeth, Farquhar, Claire A., Nolan, Kathleen F., Howie, Duncan, Lui, Kathy O., Fairchild, Paul J., Mellor, Andrew L., Ron, David, Waldmann, Herman
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704109/
https://ncbi.nlm.nih.gov/pubmed/19567830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903919106
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