Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

Mutations in the VHL tumor suppressor gene result in constitutive expression of many hypoxia-inducible genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF1α, which in normal cells is rapidly ubiquitinated and degraded by the proteasome und...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Kamura, Takumi, Sato, Shigeo, Iwai, Kazuhiro, Czyzyk-Krzeska, Maria, Conaway, Ronald C., Conaway, Joan Weliky
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27041/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10973499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190332597
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